Use Of Placental Stem Cells for Treatment

• Use of placental stem cells for treatment

Regenerative medicine is rapidly evolving. This field often utilizes multipotent mesenchymal stem cells (MMSCs), which have special abilities. These cells can develop into bone, fat, nerve, cartilage, and muscle cells. They can also form microvascular-like structures. When used targetedly, they can help initiate the healing process, improving the function of damaged tissue.

Cells used to treat various diseases come in two types: autologous (your own cells, usually taken from bone marrow or fatty tissue) and allogeneic (donated cells, such as those from the placenta).

Donated human placenta is one of the primary sources of biological material needed to produce cellular products from one person to another. The placenta is an organ that forms in the uterus during pregnancy and helps the fetus grow and function properly while inside. After the baby is born, the placenta is no longer needed; it exits the uterus shortly after birth, completing its function. It can then be frozen in small pieces for long-term use to treat certain diseases and improve health later on.

The difference between stem cells derived from allogeneic placental tissue and MMSCs derived from bone marrow or adipose tissue

After comparison, it was found that stem cells from the placenta multiply more readily than stem cells from other locations. This is important for producing sufficient cell products for treatment.

Scientists have discovered that placental MMSCs have distinct properties. They perform better and are more robust than MMSCs taken from other locations. Each cell in the placenta grows approximately twice as fast as cells from bone marrow and adipose tissue.

Because the human placenta is large and has a special structure, we can obtain more MMSCs from it. As a result, working with the cells requires fewer steps and time. This helps reduce the likelihood of any problems during their growth in the lab.

MMSCs, regardless of their source, can alter how the immune system works. They calm it, making them useful in treating conditions in which the immune system attacks the body, such as autoimmune diseases. A new study has found that stem cells taken from the placenta are better at regulating the immune system than other types of stem cells.

Using these special placental cells has another major advantage: they can be used immediately for patients who need rapid treatment. Some patients have serious illnesses or their condition worsens rapidly, so we look forward to preparing their own cells for treatment.

Furthermore, allogeneic cell products can also be used in various situations where there is no need to obtain bone marrow or adipose tissue surgically due to:

1. Presence of contraindications to anesthesia.
2. Higher chance of bleeding.
3. Long-term use of blood thinning medications.
4. The presence of a diseased process in the anatomical area intended for biopsy.

It’s sometimes difficult to obtain enough cells from a person’s body for medical purposes. This can occur when a person is very thin and doesn’t have much subcutaneous fat. It can also be difficult immediately after using fat-reducing medications.

Bone marrow cannot be removed for people with blood disorders or who are taking long-term treatments such as hormones, medications that suppress the immune system, or antibiotics because it may harm their bone marrow cells.

Stem cells taken from healthy people are usually more effective in treatment and can be used in people other than their relatives. Placental tissue cells are very young and robust, and are the most powerful cells you can obtain after a baby is born.

Placenta-derived MMSCs are very good for treatment because they have many good qualities.

Mechanism of action of placental stem cells

Once inside the body, stem cells identify damaged areas and stimulate the body’s own repair and regeneration processes. When used as a cellular therapy, MMSCs can repair damaged tissue by sending signals to and directly affecting nearby cells.

Therefore, using these cells for treatment is beneficial, as it does not require medications that may have adverse side effects or are not suitable for certain conditions. It also does not require surgery, which may not be desirable or feasible due to the patient’s age, health condition, or other logical reasons. 

What diseases can be treated with placenta cells?

Stem cells can help treat many different tissue-related diseases. These include digestive problems, diabetes, heart disease, asthma, and allergies, as well as various neurological conditions such as Alzheimer’s, autism, and multiple sclerosis. Stem cells have special abilities that help the body recover from these medical conditions.

Placenta-based products can help make a person healthier and younger.

How does placental stem cell treatment work?

Before treatment, the biomaterial is stored in a special bank after being frozen in liquid nitrogen. When needed, we thaw the cells and grow them until we have enough for the treatment. Once ready, we administer the cellular product to the patient. This can be done by injecting it into the bloodstream, injecting it into the muscle, or placing it directly in the desired location.

Products made from stem cells found in placental tissue are available without the need for surgery. They can be used immediately for medical purposes. Patients do not need to undergo a lengthy and painful process to grow some of their own cells.

After receiving stem cell therapy, most people can return to their normal lives immediately, as the recovery period is very short. Occasionally, a fever may occur after the procedure, either during or afterward. However, there’s no need to worry, as the fever usually goes away on its own and causes no harm to the patient.

Risks and side effects of placental MMSC cells

Placental cells meet all the criteria to be called pluripotent mesenchymal stem cells, according to the latest criteria set by the International Society for Cellular Therapy.

Multipotent matrix metal stem cells (MMSCs) are special cells that are not easily detected by the immune system. This means they integrate into the body without causing any problems, even if they come from another person. Therefore, they are safe to use in treatments without the risk of rejection. These special cells are derived from females, but they are important for everyone, not just women.

Before use, scientists examine the biological cell material to ensure it meets certain criteria, which include a sufficiently high percentage of living cells, protection against DNA viruses, and inactivity against microscopic bacteria and fungi.

Ethical questions about the use of placental tissue cells. Who donated them?

Many pregnant women choose to donate their placenta for stem cell research after giving birth. They sign a form authorizing the use of the placenta for scientific purposes, as well as its use to help patients. Thus, the placenta helps in areas other than its primary function.

Placental cells have many functions and are a good alternative to embryonic stem cells. The use of embryonic stem cells is problematic, as some believe it is inaccurate. During pregnancy, stem cells are not collected from the placenta, and they are not associated with termination of pregnancy. After the baby is born, a placenta biopsy, or a small piece of it, is taken. This occurs after the placenta has ceased its function; otherwise, it would be discarded as medical waste. No one is paid to donate their placenta for stem cell research, meaning there is no underground market for placentas.

Therefore, using stem cells from placental tissue for sampling is completely safe and harmless to the donor. It is completely legal and complies with all laws in the countries where it is performed.

How can placental stem cells be used to treat patients?

It’s important to know that stem cell therapy is only one part of the comprehensive treatment we offer. Depending on the patient’s current needs, their treatment may include preparation for the procedure, followed by exercises and therapies. This may include things like physical therapy, drug-free needles (dry needling), the use of a special light (laser or ultraviolet light) on the blood, a specific type of brain stimulation called midbrain modulation, inhalation of a special gas called xenon, and more.

We develop a personalized plan based on your needs to achieve the best possible results. Treatment may help temporarily cure some conditions, prevent them from worsening, or help them gradually improve.

Before you make your decision, you can speak with our online medical advisor for advice.

• To find out if treatment will help you and what type of treatment may be best for your condition.
• To learn about everything related to our programs.

We don’t offer  placental stem cell therapy  to everyone. We can suggest a treatment plan using cell products if we believe they may help treat a particular disease and its specific features. Let’s discuss what you want and what you hope to gain from the treatment.